@gauravsabnis @bhalomanush I think it is both. Don’t know if you read the whole string of replies back and forth here. It is great but, I am skeptical about its real life utility.
Read more@bhalomanush @gauravsabnis yeah yeah yeah. I am kidding. It is hard to get BS past editors and reviewers from Nature.
Read more@bhalomanush @gauravsabnis They must have a great marketing team at DeepMind. 😉😉
Read more@bhalomanush I agree it is a great effort but I am skeptical. I’ll believe it when experimentally determined structure of a novel protein matches its predicted structure. ✌️✌️
Read more@bhalomanush I think 42% residues without confident prediction is very high. Predicting the overall fold of another kinase or a polymerase without getting the nitty-gritty details of the binding site is useless.
Read more@bhalomanush From my experience, in many cases the interesting parts of the protein, i.e. active site in an enzyme or a binding surface in protein-protein interaction, are not well defined and can’t be seen in experimentally determined structures. I suspect this will make up 42% of residues.
Read more@bhalomanush Sounds like a marketing brochure for AlphaFold. :)
Read more@bhalomanush “The resulting dataset covers 58% of residues with a confident prediction, of which a subset (36% of all residues) have very high confidence.” Just a numbers game here! Only a hype, IMHO.
Read more@syndrome22q1 #HiJustin How are you doing?
Read moreSo nice! Made my day! twitter.com/davidgura/stat…
Read moreIn retrospect, I was quite stupid 20+ years ago and said many idiotic things but, don’t think that way anymore.
Read moreHearing news about sacking of several people from Japan associated with Tokyo Olympics because of their comments and actions from 20 years ago. People change; their thinking evolves. If they still hold those views now, then removing them makes sense. 20 years is a long time.
Read moreDoes anyone really go for his concerts anymore? twitter.com/NPR/status/141…
Read moreAlewife cove in Waterford, CT. t.co/5u3RAxWhm…
Read moreJust now saw the headline that last night Bucks won the NBA final. Had no idea. Can’t believe how seriously I used to follow NBA about 15-20 years ago.
Read more@curiousgawker Nice! Let me know how the bidet works. I have been thinking about upgrading my toilet.
Read more@_s_hari I don’t see a problem with these 2 things you point out. it is convenient if you have a credit card that expires. it is very easy to create teen accounts and set them up so they have to ask permission to proceed with purchase. Also, purchase limits.
Read moreBrady trying to redeem himself. twitter.com/DavidYankovich…
Read moreThe effectiveness of Covid vaccines in one picture. twitter.com/abuttenheim/st…
Read moreWhy? twitter.com/ShaneGoldmache…
Read moreHa aha haa ha!!! twitter.com/jamiedupree/st…
Read moreThread about this London-Amsterdam bike ride we did 2 years ago. Want to go back for another similar Europe trip but don’t know when it will happen. Hopefully, Spring/Summer of 2022. twitter.com/parags/status/…
Read more@k_rupal @gauravsabnis @brandybruja Me, too! IMHO, if bollywood had closed shop after ‘Chalti kaa naam gaadi’, it would have been just fine. That is the best bollywood movie ever.
Read more@k_rupal I have given up on bollywood long long time ago.
Read moreHere is an example of a situation resulting from this misinformation. twitter.com/ImTheQ/status/…
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